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Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?
Eijsvoogel, Noortje B; Hollegien, Mirjam I; Bok, Vinus L A; Derksen Lubsen, Arda G; Dikken, Felix P J; Leenders, Sander A C A P; Pijning, Arjan; Post, Erica; Wojciechowski, Marek; Hilbink, Mirrian; de Vries, Esther.
Afiliación
  • Eijsvoogel NB; Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
  • Hollegien MI; Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
  • Bok VLA; Department of Pediatrics, Màxima Medical Centre, Veldhoven, The Netherlands.
  • Derksen Lubsen AG; Department of Pediatrics, Juliana Children's Hospital/Haga Hospital, The Hague, The Netherlands.
  • Dikken FPJ; Department of Pediatrics, Gelre Hospital, Zutphen, The Netherlands.
  • Leenders SACAP; Department of Medical Microbiology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
  • Pijning A; Department of Pediatrics, Slingeland Hospital, Doetinchem, The Netherlands.
  • Post E; Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Wojciechowski M; Department of Pediatrics, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium.
  • Hilbink M; Jeroen Bosch Academy, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
  • de Vries E; Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
J Med Virol ; 89(9): 1682-1685, 2017 09.
Article en En | MEDLINE | ID: mdl-28322457
ABSTRACT
We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Vacunas contra Hepatitis B / Síndrome de Down / Hepatitis B / Anticuerpos contra la Hepatitis B Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Med Virol Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Vacunas contra Hepatitis B / Síndrome de Down / Hepatitis B / Anticuerpos contra la Hepatitis B Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Med Virol Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos