Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C.
Rev Soc Bras Med Trop
; 50(1): 113-116, 2017.
Article
en En
| MEDLINE
| ID: mdl-28327812
ABSTRACT
INTRODUCTION:
Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis.METHODS:
RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression.RESULTS:
The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB.CONCLUSIONS:
A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento Derivado de Plaquetas
/
Hepatitis C Crónica
/
Proteínas Proto-Oncogénicas c-sis
/
Factor de Crecimiento Transformador beta1
/
Cirrosis Hepática
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil