A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure.
Chem Asian J
; 12(9): 949-953, 2017 May 04.
Article
en En
| MEDLINE
| ID: mdl-28328174
ABSTRACT
Hyperpolarization is an emerging method that dramatically enhances NMR signal intensity. As a result of their increased sensitivity, hyperpolarized (HP) NMR molecular probes can be used to perform time-resolved spectroscopy and imaging in vitro and in vivo. It is, however, challenging to design such probes de novo. Herein, the [1-13 C]α-amino acid is reported as a scaffold structure to design HP 13 Câ
NMR molecular probes. The [1-13 C]α-amino acid can be converted to various HP 13 C chemical probes that show sufficient chemical shift change by altering the chemical state of the α nitrogen upon interaction with the target. Several previously reported HP probes could be explained by this design principle. To demonstrate the versatility of this approach, two α-amino-acid-based HP 13 C chemical probes, sensitive to pH and Ca2+ ion, were developed and used to detect targets.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sondas Moleculares
/
Aminoácidos
Idioma:
En
Revista:
Chem Asian J
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón