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The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.
Kang, Hoin; Rho, Jun Gi; Kim, Chongtae; Tak, Hyosun; Lee, Heejin; Ji, Eunbyul; Ahn, Sojin; Shin, A-Ri; Cho, Hyun-Il; Huh, Yun Hyun; Song, Woo Keun; Kim, Wook; Lee, Eun Kyung.
Afiliación
  • Kang H; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Rho JG; Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
  • Kim C; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Tak H; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Lee H; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Ji E; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Ahn S; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Shin AR; Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, South Korea.
  • Cho HI; Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, South Korea.
  • Huh YH; Department of Life Science, Bio Imaging and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Song WK; Department of Life Science, Bio Imaging and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, South Korea.
  • Kim W; Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
  • Lee EK; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Sci Rep ; 7: 44847, 2017 03 24.
Article en En | MEDLINE | ID: mdl-28337997
ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / MicroARNs / Interferencia de ARN / Proteína Sustrato Asociada a CrK Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Corea del Sur
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / MicroARNs / Interferencia de ARN / Proteína Sustrato Asociada a CrK Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Corea del Sur