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Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
Alizadeh, Javad; Zeki, Amir A; Mirzaei, Nima; Tewary, Sandipan; Rezaei Moghadam, Adel; Glogowska, Aleksandra; Nagakannan, Pandian; Eftekharpour, Eftekhar; Wiechec, Emilia; Gordon, Joseph W; Xu, Fred Y; Field, Jared T; Yoneda, Ken Y; Kenyon, Nicholas J; Hashemi, Mohammad; Hatch, Grant M; Hombach-Klonisch, Sabine; Klonisch, Thomas; Ghavami, Saeid.
Afiliación
  • Alizadeh J; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Zeki AA; Biology of Breathing Theme, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada.
  • Mirzaei N; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, Davis, CA, USA.
  • Tewary S; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Rezaei Moghadam A; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Glogowska A; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Nagakannan P; Biology of Breathing Theme, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada.
  • Eftekharpour E; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Wiechec E; Department of Physiology and Pathophysiology, Regenerative Medicine, Program and Spinal Cord research Center, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Gordon JW; Department of Physiology and Pathophysiology, Regenerative Medicine, Program and Spinal Cord research Center, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Xu FY; Department of Clinical and Experimental Moledicine, Division of Otorhinolaryngology, Linköping University, 581-85, Linköping, Sweden.
  • Field JT; Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Yoneda KY; College of Nursing and Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  • Kenyon NJ; DREAM, Children's Hospital Research Institute of Manitoba, Center for Research and Treatment of Atherosclerosis and Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
  • Hashemi M; Department of Biological Sciences, Faculty of Science, University of Manitoba, Winnipeg, Canada.
  • Hatch GM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, Davis, CA, USA.
  • Hombach-Klonisch S; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, Davis, CA, USA.
  • Klonisch T; Department of Clinical Biochemistry, Zehedan University of Medical Sciences, Zahedan, Iran.
  • Ghavami S; DREAM, Children's Hospital Research Institute of Manitoba, Center for Research and Treatment of Atherosclerosis and Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
Sci Rep ; 7: 44841, 2017 03 27.
Article en En | MEDLINE | ID: mdl-28344327
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Simvastatina / Redes y Vías Metabólicas / Ácido Mevalónico Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Canadá
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Simvastatina / Redes y Vías Metabólicas / Ácido Mevalónico Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Canadá