Ferrous [Fe++] but not ferric [Fe] ions inhibit de novo formation of calcium pyrophosphate dihydrate crystals: possible relationships to chondrocalcinosis and hemochromatosis.
J Rheumatol
; 15(2): 321-4, 1988 Feb.
Article
en En
| MEDLINE
| ID: mdl-2834554
ABSTRACT
To determine the physical-chemical effects of [Fe++] and [Fe ] on calcium pyrophosphate dihydrate (CPPD) crystal formation de novo, we studied CPPD crystal formation in an established model aqueous solution mixture system using physiological concentrations of Na+, Mg++, Ca++, C1-. We found that [Fe++] greater than 1 microM or [Fe ] greater than or equal to 100 microM inhibits CPPD crystal formation under conditions of [Ca++] = 1.5 mM, [Pi] = 0.1 mM, and [PPi] = 0.1 mM that simulate CPPD formation in vivo. These experiments suggest that at biological concentrations, Fe++ acts to inhibit CPPD formation but that [Fe++] depletion therapy by removal of inhibition effects may facilitate CPPD crystal formation in articular tissues.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirofosfato de Calcio
/
Compuestos Ferrosos
/
Condrocalcinosis
/
Difosfatos
/
Hemocromatosis
Límite:
Humans
Idioma:
En
Revista:
J Rheumatol
Año:
1988
Tipo del documento:
Article
País de afiliación:
Canadá