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Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-ß/Smad2/STAT3 signaling.
Zheng, Jin-Yu; Sun, Jian; Ji, Chun-Mei; Shen, Lin; Chen, Zhong-Jun; Xie, Peng; Sun, Yuan-Zhao; Yu, Ru-Tong.
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  • Zheng JY; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China; Department of Neurosurgery, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China.
  • Sun J; Department of Anesthesiology, Huai'an Maternal and Child Health Hospital, Huai'an, Jiangsu, P. R. China.
  • Ji CM; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.
  • Shen L; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.
  • Chen ZJ; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.
  • Xie P; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.
  • Sun YZ; Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.
  • Yu RT; Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China; Laboratory of Neurosurgery, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China. Electronic address: rutong_yu@163.com.
Neurobiol Aging ; 54: 112-132, 2017 06.
Article en En | MEDLINE | ID: mdl-28366226
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas E / Terapia Genética / Transducción de Señal / Astrocitos / Factor de Crecimiento Transformador beta / Eliminación de Gen / Proteína Smad2 / Factor de Transcripción STAT3 / Enfermedad de Alzheimer / Aprendizaje Espacial Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas E / Terapia Genética / Transducción de Señal / Astrocitos / Factor de Crecimiento Transformador beta / Eliminación de Gen / Proteína Smad2 / Factor de Transcripción STAT3 / Enfermedad de Alzheimer / Aprendizaje Espacial Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2017 Tipo del documento: Article