Experimental and bioinformatic characterization of CaBP2933 an EF-Hand protein of Giardia intestinalis.
Mol Biochem Parasitol
; 214: 65-68, 2017 06.
Article
en En
| MEDLINE
| ID: mdl-28373093
ABSTRACT
Giardia intestinalis is a parasite that inhabits the small intestine of humans. This parasite is a divergent eukaryote with a compact genome. The calcium ion is an essential messenger in cell signaling. Calcium's role as a messenger is mediated through calcium-binding proteins (CaBPs) that decode the message. The most important family of CaBPs is the EF-Hand protein family. In this study we have explored the role of EF-Hand protein CaBP2933. We analyzed its location, confirmed its ability to bind calcium and identified some of its interacting proteins. Take together our results suggest that CaBP2933 is involved in vesicular trafficking during encystation, via an interaction with kinesin-3 motor protein.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al Calcio
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Proteínas Protozoarias
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Cinesinas
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Giardia lamblia
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Motivos EF Hand
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Mol Biochem Parasitol
Año:
2017
Tipo del documento:
Article
Pais de publicación:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
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PAISES BAJOS
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THE NETHERLANDS