Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow.
J Cutan Pathol
; 44(7): 605-611, 2017 Jul.
Article
en En
| MEDLINE
| ID: mdl-28374436
ABSTRACT
BACKGROUND:
The so-called acquired elastotic hemangioma (AEH) represents a peculiar vascular lesion affecting the sun-damaged skin of the extensor surface of the forearms or the lateral aspect of the neck of middle-aged or elderly women.METHODS:
This is a clinicopathological and immunohistochemical study of a series of 6 lesions located on the knee or elbow showing epithelial features of lichen simplex chronicus (LSC)/prurigo nodularis (PN) with a marked subepidermal vascular proliferation closely resembling AEH.RESULTS:
Microscopically, all cases of cutaneous lesions showed epithelial features of LSC/PN, that is compact hyperkeratosis with focal parakeratosis, irregular acanthosis, prominent hypergranulosis. Moreover, a marked subepidermal vascular proliferation arranged in a horizontal band closely resembling AEH was detected in these lesions. Another common histopathological finding was eccrine duct squamous metaplasia and/or hyperplasia.CONCLUSIONS:
While AEH represents a distinctive clinicopathological variant of hemangioma characteristically appearing on sun-exposed areas of middle-aged or elderly patients, the herein described lesions seem to be non-neoplastic epithelial, vascular and eccrine sweat duct reactive changes which are likely to be associated with chronic pressure or repeated mechanical stimulation with a marked predilection for the knee and elbow.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Cutan Pathol
Año:
2017
Tipo del documento:
Article
País de afiliación:
República Checa