Experimental infections of wild bank voles (Myodes glareolus) from nephropatia epidemica endemic and non-endemic regions revealed slight differences in Puumala virological course and immunological responses.
Virus Res
; 235: 67-72, 2017 05 02.
Article
en En
| MEDLINE
| ID: mdl-28396283
ABSTRACT
In Europe, the occurrence of nephropathia epidemica (NE), a human disease caused by Puumala virus (PUUV), exhibits considerable geographical heterogeneity despite the continuous distribution of its reservoir, the bank vole Myodes glareolus. To better understand the causes of this heterogeneity, wild voles sampled in two adjacent NE endemic and non-endemic regions of France were infected experimentally with PUUV. The responses of bank voles to PUUV infection, based on the levels of anti-PUUV IgG and viral RNA, were compared. Slight regional differences were highlighted despite the high inter-individual variability. Voles from the NE non-endemic region showed greater immune responsiveness to PUUV infection, but lower levels of RNA in their organs than voles from the endemic region. These results suggest the existence of regional variations in the sensitivity of bank voles that could contribute to the apparent absence of PUUV circulation among voles and the absence of NE in the non-endemic region.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reservorios de Enfermedades
/
Arvicolinae
/
Virus Puumala
/
Susceptibilidad a Enfermedades
/
Fiebre Hemorrágica con Síndrome Renal
Límite:
Animals
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Virus Res
Asunto de la revista:
VIROLOGIA
Año:
2017
Tipo del documento:
Article