[Association of inflammatory genes with neuroticism, anxiety and depression in male patients with coronary heart disease]. / Sviaz' genov vospalitel'nykh faktorov s nevrotizmom, trevozhnost'iu i depressiei u muzhchin s ishemicheskoi bolezn'iu serdtsa.
Zh Nevrol Psikhiatr Im S S Korsakova
; 117(3): 74-79, 2017.
Article
en Ru
| MEDLINE
| ID: mdl-28399100
ABSTRACT
AIM:
To explore the relationship of depression and its endophenotypes (neuroticism and trait anxiety) with inflammatory genes in patients with coronary heart disease (CHD). MATERIAL ANDMETHODS:
A sample consisted of 78 male CHD patients with depression, 91 CHD patients without depression and 127 healthy men. Polymorphisms of the genes encoding interleukine-4 (IL-4 -589 C/T), interleukine-6 (IL-6 -174 G/C), tumor-necrosis factor alpha (TNF-α -308 G/A) and C-reactive protein (CRP -717A/G) were studied.RESULTS:
There was the association between the IL-6 -174 G/C and depression comorbid to CHD (Ñ=0.01; OR=2.3 CI 95% 1.2-4.3). The frequency of the 'high expression' allele G in this group was higher compared to controls. The association between IL-4 -589 C/T and CHD was found. Compared to the control group, the frequency of the IL-4 -589CC genotype was higher in patients regardless of whether they had symptoms of depression (Ñ=0.007; OR=2.1 CI 95% 1.2-3.4). No association between the TNF-α -308G/A and the CRP -717A/G with depression in CHD was observed. There were no differences between neuroticism and anxiety scores in patients with different IL-4 -589 C/T, IL-6 -174 G/C, TNF-α -308 G/A, CRP -717A/G genotypes.CONCLUSION:
The finding of the association between the IL-6 -174G/C and depression, comorbid to CHD, is in line with literature on a role of IL-6 in the development of depression in patients with CHD.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Trastornos de Ansiedad
/
Enfermedad Coronaria
/
Depresión
/
Inflamación
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Zh Nevrol Psikhiatr Im S S Korsakova
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Rusia