Expression of matrix metalloproteinase-9 and its substrate level in patients with premature rupture of membranes.
J Obstet Gynaecol
; 37(4): 441-445, 2017 May.
Article
en En
| MEDLINE
| ID: mdl-28421903
ABSTRACT
In this study, 30 case of patients with full-term premature membrane rupture and another 30 cases of full-term delivered subject without premature rupture of membranes (PROM) were selected to explore the relationship between premature membrane rupture with matrix metalloproteinase 9 (MMP-9) and its substrate level. Results showed the plasma zinc, MMP-9 in serum and amniotic fluid increased in patients with PROM; their type IV collagen in serum and foetal membrane decreased. Increased Zinc ion concentration results in increased concentration of MMP-9, a zinc-dependent enzyme; the degradation of type IV collagen by MMP-9 might be the potential mechanism of premature rupture of membranes in full-term pregnant women.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zinc
/
Rotura Prematura de Membranas Fetales
/
Metaloproteinasa 9 de la Matriz
/
Colágeno Tipo IV
/
Líquido Amniótico
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Obstet Gynaecol
Año:
2017
Tipo del documento:
Article
País de afiliación:
China