A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide-rhodamine platform and its application in live cell imaging.
Org Biomol Chem
; 15(18): 3947-3954, 2017 May 10.
Article
en En
| MEDLINE
| ID: mdl-28436528
ABSTRACT
Copper plays important roles in a variety of fundamental physiological processes. At the cell organelle level, aberrant copper homeostasis in lysosomes can lead to various serious diseases. Herein, a bifluorophore-based, lysosome-targetable Cu2+-selective ratiometric fluorescent probe (V) has been synthesized by reasonable design. The probe V shows high selectivity toward Cu2+ ions over other cations and exhibits high sensitivity (1.45 nM) for the detection of Cu2+ ions. Meanwhile, the probe is cell permeable and suitable for ratiometric visualization of lysosomal Cu2+ in the living cell.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rodaminas
/
Cobre
/
Naftalimidas
/
Límite de Detección
/
Imagen Óptica
/
Colorantes Fluorescentes
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
China