An investigation into the effects of maternal supplementation with excess iodine on the mechanisms and impacts of reduced IgG absorption in the lamb postpartum.
Br J Nutr
; 117(7): 951-963, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-28443527
ABSTRACT
An experiment was conducted to determine (1) the effect of excess maternal I supplementation on the thyroid hormone status of the ewe and her progeny; (2) potential mechanisms underpinning the failure of passive transfer associated with excess I and (3) the growing lambs' response to natural gastrointestinal infection. Twin-bearing ewes received one of two treatments (n 32/treatment group) basal diet (C) or C plus 26·6 mg of iodine/ewe per d (I), supplied as calcium iodate. Ewes were individually fed from day 119 of gestation to parturition. Progeny of I ewes had lower (P<0·01) serum IgG concentrations from 24 h to 28 d postpartum but higher serum IgG concentrations at day 70 postpartum (P<0·05). I supplementation increased the relative expression of Fc receptor, IgA, IgM high affinity and polymeric Ig receptor in the ileum of the lamb at 24 h postpartum; however, thyroid hormone receptor-ß (THRB) and ß-2-microglobulin (B2M) expression declined (P<0·05). Progeny of I ewes had higher growth rates to weaning (P<0·05) and lower faecal egg count (FEC) for Nematodirus battus (P<0·05) between weeks 6 and 10 postpartum. In conclusion, excess maternal I supplementation negatively affected the thyroid hormone status, serum IgG concentration, ileal morphology and the gene expression of THRB and B2M in the ileum and ras-related protein (RAB) RAB25 and the mucin gene (MUC) MUC1 in the duodenum of the lamb postpartum. These effects were followed by an enhancement of average daily gain and lower N. battus FEC in the pre-weaning period of I-supplemented lambs.
Palabras clave
B2M ß-2-microglobulin; BCS body condition score; C basal diet; CD crypt depth; CP crude protein; FEC faecal egg count; FEC faecal egg count for Nematodirus battus; FPT failure of passive transfer; FcRn neonatal Fc receptor; I C plus 26·6 mg of I/ewe per d; ME metabolisable energy; MUC mucin genes; RAB ras-related protein; T thyroxine; T tri-iodothyronine; VH villus height; Colostrum IgG; Ewes; Iodine; Nutrition; Pregnancy
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de las Ovejas
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Infecciones por Strongylida
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Calostro
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Suplementos Dietéticos
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Fenómenos Fisiologicos Nutricionales Maternos
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Inmunidad Materno-Adquirida
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Yodo
Idioma:
En
Revista:
Br J Nutr
Año:
2017
Tipo del documento:
Article