Choreography of parental histones in damaged chromatin.
Nucleus
; 8(3): 255-260, 2017 05 04.
Article
en En
| MEDLINE
| ID: mdl-28448742
ABSTRACT
In the cell nucleus, DNA repair machineries operate on a chromatin substrate, whose integrity is key for preserving cell functions and identity. Yet, it is still unclear how the epigenetic information conveyed by chromatin is maintained during the DNA repair process. We recently characterized the dynamics of parental histones coupled to UV-C damage repair in human cells, providing insights into how the pre-damage chromatin state may be restored. Here, we summarize our main findings and discuss them in the context of epigenome maintenance following DNA damage. We further address the mechanistic aspects of repair-coupled histone dynamics and develop working hypotheses regarding their functional relevance in the cellular response to genotoxic stress.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromatina
/
Histonas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Nucleus
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia