Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge.
J Nat Prod
; 80(5): 1575-1583, 2017 05 26.
Article
en En
| MEDLINE
| ID: mdl-28452477
ABSTRACT
Five new manzamine alkaloids (1-5) and new salt forms of two known manzamines (6 and 7), along with seven known compounds (8-14) of the same structural class, were isolated from an Indonesian Acanthostrongylophora sp. sponge. On the basis of the results of combined spectroscopic analyses, the structure of kepulauamine A (1) was determined to possess an unprecedented pyrrolizine moiety, while others were functional group variants of known manzamines. These compounds exhibited weak cytotoxicity, moderate antibacterial activity, and mild inhibition against the enzyme isocitrate lyase.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirrolnitrina
/
Carbazoles
/
Isocitratoliasa
/
Antibacterianos
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2017
Tipo del documento:
Article