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Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.
Doering, Skye R; Freeman, Katie T; Schnell, Sathya M; Haslach, Erica M; Dirain, Marvin; Debevec, Ginamarie; Geer, Phaedra; Santos, Radleigh G; Giulianotti, Marc A; Pinilla, Clemencia; Appel, Jon R; Speth, Robert C; Houghten, Richard A; Haskell-Luevano, Carrie.
Afiliación
  • Doering SR; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  • Freeman KT; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  • Schnell SM; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  • Haslach EM; Department of Pharmacodynamics, University of Florida , Gainesville, Florida 32610, United States.
  • Dirain M; Department of Pharmacodynamics, University of Florida , Gainesville, Florida 32610, United States.
  • Debevec G; Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987, United States.
  • Geer P; Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987, United States.
  • Santos RG; Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987, United States.
  • Giulianotti MA; Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987, United States.
  • Pinilla C; Torrey Pines Institute for Molecular Studies , San Diego, California 92121, United States.
  • Appel JR; Torrey Pines Institute for Molecular Studies , San Diego, California 92121, United States.
  • Speth RC; College of Pharmacy, Nova Southeastern University , Fort Lauderdale, Florida 33328, United States.
  • Houghten RA; Department of Pharmacology and Physiology, Georgetown University , Washington, D.C. 20057, United States.
  • Haskell-Luevano C; Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987, United States.
J Med Chem ; 60(10): 4342-4357, 2017 05 25.
Article en En | MEDLINE | ID: mdl-28453292
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Receptor de Melanocortina Tipo 3 / Receptor de Melanocortina Tipo 4 Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Receptor de Melanocortina Tipo 3 / Receptor de Melanocortina Tipo 4 Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos