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Dibenzocyclooctadiene lignans from Kadsura heteroclita.
Luo, Yuan-Qing; Liu, Miao; Wen, Jin; Wang, Wei-Guang; Hu, Kun; Li, Xiao-Nian; Du, Xue; Pu, Jian-Xin; Sun, Han-Dong.
Afiliación
  • Luo YQ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Liu M; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Wen J; Yunnan Academy of Forest Sciences Institute of Tropical Forestry, Kunming 650204, People's Republic of China.
  • Wang WG; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
  • Hu K; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
  • Du X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
  • Pu JX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China. Electronic address: pujianxin@mail.kib.ac.cn.
  • Sun HD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China. Electronic address: hdsun@mail.kib.ac.cn.
Fitoterapia ; 119: 150-157, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28457823
ABSTRACT
Sixteen dibenzocyclooctadiene lignans, including eight new ones, kadheterins A-H (1-8), and a new natural product, 9-benzoyloxy-gomisin B (9), were isolated from the stems of K. heteroclita. The structures of 1-9 were elucidated by extensive spectroscopic methods, and their absolute configurations were determined by combining CD with ROESY experiments. Additionally, the absolute configuration of 1 was further confirmed by single crystal X-ray crystallographic analysis. In vitro activity assays showed that 1 exhibited moderate cytotoxicity against HL-60 with IC50 value at 14.59µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Kadsura / Ciclooctanos Límite: Animals / Humans Idioma: En Revista: Fitoterapia Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Kadsura / Ciclooctanos Límite: Animals / Humans Idioma: En Revista: Fitoterapia Año: 2017 Tipo del documento: Article