18F-FPP: A PET Ligand for the 5-HT2C Receptor?
ACS Chem Neurosci
; 8(5): 904-907, 2017 05 17.
Article
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| MEDLINE
| ID: mdl-28459529
In the current issue of ACS Chemical Neuroscience, Kim et al. report on the early characterization of 4-(3-[18F] fluorophenethoxy)pyrimidine (18F-FPP) as a new positron emission tomography radiotracer for imaging brain 5-HT2C receptors ( Kim, J., et al. ( 2017 ) A potential PET radiotracer for the 5-HT2c receptor: Synthesis and in vivo evaluation of 4-(3-[18F]Fluorophenethoxy)pyrimidine. ACS Chem. Neurosci. , DOI: 10.1021/acschemneuro.6b00445 ). At the present time, the tracer properties of 18F-FPP have only been reported in rats. If 18F-FPP is indeed shown to be suitable as a 5-HT2C receptor PET tracer in humans, it will very likely have an important impact both in the development of any new chemical entities (NCEs) targeted to 5-HT2C receptors, as well as a tool to advance understanding of 5-HT2C receptor function both in normal and abnormal brain states.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radioisótopos de Flúor
/
Receptor de Serotonina 5-HT2C
Límite:
Animals
/
Humans
Idioma:
En
Revista:
ACS Chem Neurosci
Año:
2017
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos