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Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.
Estridge, Thomas B; Dey, Asim B; Reidy, Charles; Yu, Xiaohong; Zhang, Yuke; Hartley, Maryalice; Milligan, Paul L; Jin, Najia; Kowala, Mark C; Leohr, Jennifer K; Fretland, Adrian J; Mabry, Thomas E; Luffer-Atlas, Debra; Luo, M Jane.
Afiliación
  • Estridge TB; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Dey AB; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Reidy C; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Yu X; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Zhang Y; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Hartley M; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Milligan PL; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Jin N; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Kowala MC; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Leohr JK; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Fretland AJ; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Mabry TE; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Luffer-Atlas D; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana.
  • Luo MJ; CardioMet Disease/Diabetic Complications (T.B.E., A.B.D., C.R., X.Y., Y.Z., N.J., M.H., M.C.K, M.J.L.), Discovery Chemistry and Research Technologies (P.L.M., T.E.M.), Global PK/PD & Pharmacometrics (J.K.L.), Drug Disposition (A.J.F., D.L.-A.), Eli Lilly & Co., Indianapolis, Indiana luomi@li
J Pharmacol Exp Ther ; 362(1): 108-118, 2017 07.
Article en En | MEDLINE | ID: mdl-28465372
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Adenina / Hipolipemiantes / Obesidad Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Adenina / Hipolipemiantes / Obesidad Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos