Room Temperature X-Ray Crystallography Reveals Conformational Heterogeneity of Engineered Proteins.
Structure
; 25(5): 691-692, 2017 05 02.
Article
en En
| MEDLINE
| ID: mdl-28467914
ABSTRACT
In this issue of Structure, Biel et al. (2017) present multi-conformer analyses from room temperature X-ray data of two ubiquitin phage display variants binding deubiquitinase USP7. The first contains core mutations. The second matured variant contains additional surface mutations. Alternate conformations detected in the core mutant were removed by maturation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas
/
Ubiquitina
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Structure
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2017
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA