Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.

Yue, Xin; Zuo, Yinglin; Ke, Hongpeng; Luo, Jiaming; Lou, Lanlan; Qin, Wenjing; Wang, Youqiao; Liu, Ziyi; Chen, Daoyuan; Sun, Haixia; Zheng, Weichao; Zhu, Cuige; Wang, Ruimin; Wen, Gesi; Du, Jun; Zhou, Binhua; Bu, Xianzhang

Yue, Xin; Zuo, Yinglin; Ke, Hongpeng; Luo, Jiaming; Lou, Lanlan; Qin, Wenjing; Wang, Youqiao; Liu, Ziyi; Chen, Daoyuan; Sun, Haixia; Zheng, Weichao; Zhu, Cuige; Wang, Ruimin; Wen, Gesi; Du, Jun; Zhou, Binhua; Bu, Xianzhang.

Afiliación

Yue X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Zuo Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co., Ltd, Dongguan 523871, China.
Ke H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Luo J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Lou L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Qin W; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Wang Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Liu Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Chen D; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Sun H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Zheng W; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Zhu C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Wang R; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Wen G; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Du J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Zhou B; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: zhoubh5@mail.sysu.edu.cn.
Bu X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: phsbxzh@mail.sysu.edu.cn.

Biochem Pharmacol ; 137: 29-50, 2017 08 01.

Article en En | MEDLINE | ID: mdl-28476333

Asunto(s)

Antineoplásicos/farmacología; Curcumina/análogos & derivados; Curcumina/farmacología; Enzimas Desubicuitinizantes/antagonistas & inhibidores; Complejo de la Endopetidasa Proteasomal; Inhibidores de Proteasoma/farmacología; Células A549; Animales; Antineoplásicos/química; Células CHO; Proliferación Celular/efectos de los fármacos; Proliferación Celular/fisiología; Cricetinae; Cricetulus; Enzimas Desubicuitinizantes/metabolismo; Relación Dosis-Respuesta a Droga; Sistemas de Liberación de Medicamentos/métodos; Humanos; Complejo de la Endopetidasa Proteasomal/metabolismo; Inhibidores de Proteasoma/química

Palabras clave

(1E,6E)-4-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-1,7-bis(345-trimethoxyphenyl)hepta-1,6-diene-3,5-dione (33: PubChem CID:123132175); (1E,6E)-4-(4-Hydroxy-3,5-dimethoxybenzylidene)-1,7-bis(3,4,5-trimethoxyphenyl)hepta-1,6-diene-3,5-dione (34: PubChemCID:123132176); 19S regulatory particle; 3,4,5-Trimethoxybenzaldehyde (PubChem CID:6858); Acetylacetone (PubChem CID: 31261); Anticancer; Bortezomib (PubChem CID: 387447); Curcumin (PubChem CID: 969516); Curcumin analogues; Deubiquitinase; Proteasome; n-Butylamine (PubChem CID: 8007)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Curcumina / Complejo de la Endopetidasa Proteasomal / Inhibidores de Proteasoma / Enzimas Desubicuitinizantes / Antineoplásicos Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biochem Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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