Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis.
J Epidemiol Community Health
; 71(8): 817-826, 2017 08.
Article
en En
| MEDLINE
| ID: mdl-28490476
ABSTRACT
BACKGROUND:
Inflammation plays a central role in cardiometabolic disease and may represent a mechanism linking low socioeconomic status (SES) in early life and adverse cardiometabolic health outcomes in later life. Accumulating evidence suggests an association between childhood SES and adult inflammation, but findings have been inconsistent.METHODS:
We conducted a systematic review and meta-analysis of observational studies to quantify the association between childhood (age <18â years) SES and the inflammatory marker C reactive protein (CRP) in adulthood. Studies were identified in Medline and Embase databases, and by reviewing the bibliographies of articles published from 1946 to December 2015. Study-specific estimates were combined into meta-analyses using random-effects models.RESULTS:
15 of 21 eligible studies (n=43â 629) were ultimately included in two separate meta-analyses. Compared with those from the most advantaged families, participants from the least advantaged families had 25% higher CRP levels (ratio change in geometric mean CRP 1.25; 95% CI 1.19 to 1.32) in minimally adjusted analyses. This finding was attenuated by the inclusion of adult body mass index (BMI) in adjusted models, suggesting BMI has a strong mediating role in CRP levels.CONCLUSIONS:
We observed an inverse association between childhood SES and adulthood CRP, potentially mediated through BMI. Investigating how childhood SES is associated with childhood BMI and CRP would provide insight into the effective timing of social and clinical interventions to prevent cardiometabolic disease.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Clase Social
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Proteína C-Reactiva
Tipo de estudio:
Observational_studies
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Prognostic_studies
/
Systematic_reviews
Aspecto:
Determinantes_sociais_saude
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Equity_inequality
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Epidemiol Community Health
Año:
2017
Tipo del documento:
Article
País de afiliación:
Australia