BASP1 interacts with oestrogen receptor α and modifies the tamoxifen response.
Cell Death Dis
; 8(5): e2771, 2017 05 11.
Article
en En
| MEDLINE
| ID: mdl-28492543
ABSTRACT
Tamoxifen binds to oestrogen receptor α (ERα) to elicit distinct responses that vary by cell/tissue type and status, but the factors that determine these differential effects are unknown. Here we report that the transcriptional corepressor BASP1 interacts with ERα and in breast cancer cells, this interaction is enhanced by tamoxifen. We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. In all, 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1 dependent, including several genes that are associated with tamoxifen resistance. BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the antitumourigenic effects of tamoxifen treatment. Moreover, BASP1 is expressed in breast cancer tissue and is associated with increased patient survival. Our data have identified BASP1 as an ERα cofactor that has a central role in the transcriptional and antitumourigenic effects of tamoxifen.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Tamoxifeno
/
Transcripción Genética
/
Neoplasias de la Mama
/
Regulación Neoplásica de la Expresión Génica
/
Receptor alfa de Estrógeno
/
Proteínas de la Membrana
/
Proteínas de Neoplasias
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Cell Death Dis
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido