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Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor.
Kornahrens, Anne F; Cognetta, Armand B; Brody, Daniel M; Matthews, Megan L; Cravatt, Benjamin F; Boger, Dale L.
Afiliación
  • Kornahrens AF; Departments of Chemistry, and ‡Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Cognetta AB; Departments of Chemistry, and ‡Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Brody DM; Departments of Chemistry, and ‡Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Matthews ML; Departments of Chemistry, and ‡Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Cravatt BF; Departments of Chemistry, and ‡Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Boger DL; Departments of Chemistry, and ‡Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc ; 139(20): 7052-7061, 2017 05 24.
Article en En | MEDLINE | ID: mdl-28498651
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Inhibidores de Serina Proteinasa / Lipasa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Inhibidores de Serina Proteinasa / Lipasa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos