Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.
Future Med Chem
; 9(8): 781-795, 2017 05.
Article
en En
| MEDLINE
| ID: mdl-28504917
ABSTRACT
Alzheimer's disease (AD) is the most common form of dementia affecting millions of patients worldwide which can only be treated with symptomatic drugs. Among the numbers of biological targets which are today explored in order to prevent or limit the progression of AD, the modulation of 5-HT6R and 5-HT4R appeared to be promising. This modulation has been proved to enhance the cognition in AD through modulation of the neurotransmitter system but could also be beneficial in order to limit the amyloid pathology. This review will describe recent advances in the understanding of this modulation as well as the medicinal chemistry of 5-HT6R or 5-HT4R ligands from synthesis to ongoing clinical trials.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antagonistas de la Serotonina
/
Receptores de Serotonina
/
Enfermedad de Alzheimer
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia