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Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases.
Nakabo, Shuichiro; Yoshifuji, Hajime; Hashimoto, Motomu; Imura, Yoshitaka; Nakashima, Ran; Murakami, Kosaku; Kuramoto, Nobuo; Ito, Shinji; Satoh, Junko; Tanaka, Masao; Fujii, Takao; Mimori, Tsuneyo; Ohmura, Koichiro.
Afiliación
  • Nakabo S; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
  • Yoshifuji H; S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Ass
  • Hashimoto M; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
  • Imura Y; S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Ass
  • Nakashima R; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
  • Murakami K; S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Ass
  • Kuramoto N; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
  • Ito S; S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Ass
  • Satoh J; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
  • Tanaka M; S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Ass
  • Fujii T; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
  • Mimori T; S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Ass
  • Ohmura K; From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
J Rheumatol ; 44(9): 1384-1388, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28507178
ABSTRACT

OBJECTIVE:

Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.

METHODS:

The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.

RESULTS:

The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.

CONCLUSION:

Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Autoanticuerpos / Enfermedades del Tejido Conjuntivo Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Año: 2017 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Autoanticuerpos / Enfermedades del Tejido Conjuntivo Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Año: 2017 Tipo del documento: Article País de afiliación: Japón