First total synthesis of concavine.
Chem Sci
; 8(5): 3384-3389, 2017 May 01.
Article
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| MEDLINE
| ID: mdl-28507709
ABSTRACT
The synthesis of the unusual alkaloid concavine, isolated from Clitocybe concava (Basidiomycetae), has been accomplished. The synthetic route features regio- and stereoselective manipulation of polycyclic imide intermediates via enolate substitution and Grignard addition, along with a key bridge-forming step involving a new method for sulfenylative radical cyclisation. The NMR data for synthetic concavine demonstrate that the original data reported for the natural product refer to the derived acetic acid salt, probably formed as an artefact of isolation or purification.
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01-internacional
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MEDLINE
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En
Revista:
Chem Sci
Año:
2017
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Article