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Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins.
Hashemi, Marjan M; Rovig, John; Weber, Scott; Hilton, Brian; Forouzan, Mehdi M; Savage, Paul B.
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  • Hashemi MM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
  • Rovig J; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
  • Weber S; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
  • Hilton B; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
  • Forouzan MM; Department of Chemical Engineering, Brigham Young University, Provo, Utah, USA.
  • Savage PB; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA pbs@byu.edu.
Antimicrob Agents Chemother ; 61(8)2017 08.
Article en En | MEDLINE | ID: mdl-28584137
The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest that there are differences in the resistance mechanisms to colistin and ceragenins/AMPs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Esteroides / Colistina / Péptidos Catiónicos Antimicrobianos / Acinetobacter baumannii / Klebsiella pneumoniae / Antibacterianos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Esteroides / Colistina / Péptidos Catiónicos Antimicrobianos / Acinetobacter baumannii / Klebsiella pneumoniae / Antibacterianos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos