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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.
Cho, Choi-Fong; Wolfe, Justin M; Fadzen, Colin M; Calligaris, David; Hornburg, Kalvis; Chiocca, E Antonio; Agar, Nathalie Y R; Pentelute, Bradley L; Lawler, Sean E.
Afiliación
  • Cho CF; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wolfe JM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Fadzen CM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Calligaris D; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Hornburg K; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Chiocca EA; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Agar NYR; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Pentelute BL; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Lawler SE; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nat Commun ; 8: 15623, 2017 06 06.
Article en En | MEDLINE | ID: mdl-28585535
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Biológico / Barrera Hematoencefálica / Uniones Estrechas / Esferoides Celulares Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Biológico / Barrera Hematoencefálica / Uniones Estrechas / Esferoides Celulares Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido