Your browser doesn't support javascript.
loading
5-HT2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress.
Jaggar, Minal; Weisstaub, Noelia; Gingrich, Jay A; Vaidya, Vidita A.
Afiliación
  • Jaggar M; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
  • Weisstaub N; Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina.
  • Gingrich JA; Department of Psychiatry, Columbia University, New York, United States.
  • Vaidya VA; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Neurobiol Stress ; 7: 89-102, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28626787
ABSTRACT
Chronic stress enhances risk for psychiatric disorders, and in animal models is known to evoke depression-like behavior accompanied by perturbed neurohormonal, metabolic, neuroarchitectural and transcriptional changes. Serotonergic neurotransmission, including serotonin2A (5-HT2A) receptors, have been implicated in mediating specific aspects of stress-induced responses. Here we investigated the influence of chronic unpredictable stress (CUS) on depression-like behavior, serum metabolic measures, and gene expression in stress-associated neurocircuitry of the prefrontal cortex (PFC) and hippocampus in 5-HT2A receptor knockout (5-[Formula see text]) and wild-type mice of both sexes. While 5-[Formula see text] male and female mice exhibited a baseline reduced anxiety-like state, this did not alter the onset or severity of behavioral despair during and at the cessation of CUS, indicating that these mice can develop stress-evoked depressive behavior. Analysis of metabolic parameters in serum revealed a CUS-evoked dyslipidemia, which was abrogated in 5-[Formula see text] female mice with a hyperlipidemic baseline phenotype. 5-[Formula see text] male mice in contrast did not exhibit such a baseline shift in their serum lipid profile. Specific stress-responsive genes (Crh, Crhr1, Nr3c1, and Nr3c2), trophic factors (Bdnf, Igf1) and immediate early genes (IEGs) (Arc, Fos, Fosb, Egr1-4) in the PFC and hippocampus were altered in 5-[Formula see text] mice both under baseline and CUS conditions. Our results support a role for the 5-HT2A receptor in specific metabolic and transcriptional, but not behavioral, consequences of CUS, and highlight that the contribution of the 5-HT2A receptor to stress-evoked changes is sexually dimorphic.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Neurobiol Stress Año: 2017 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Neurobiol Stress Año: 2017 Tipo del documento: Article País de afiliación: India