Fragment Binding to ß-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches.

Rombouts, Frederik J R; Alexander, Richard; Cleiren, Erna; De Groot, Alex; Carpentier, Michel; Dijkmans, Joyce; Fierens, Katleen; Masure, Stefan; Moechars, Diederik; Palomino-Schätzlein, Martina; Pineda-Lucena, Antonio; Trabanco, Andrés A; Van Glabbeek, Daan; Vos, Ann; Tresadern, Gary

Rombouts, Frederik J R; Alexander, Richard; Cleiren, Erna; De Groot, Alex; Carpentier, Michel; Dijkmans, Joyce; Fierens, Katleen; Masure, Stefan; Moechars, Diederik; Palomino-Schätzlein, Martina; Pineda-Lucena, Antonio; Trabanco, Andrés A; Van Glabbeek, Daan; Vos, Ann; Tresadern, Gary.

Afiliación

Rombouts FJR; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Alexander R; Discovery Sciences, Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.
Cleiren E; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
De Groot A; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Carpentier M; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Dijkmans J; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Fierens K; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Masure S; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Moechars D; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Palomino-Schätzlein M; Structural Biochemistry Laboratory, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera, 3, 46012 Valencia, Spain.
Pineda-Lucena A; Structural Biochemistry Laboratory, Centro de Investigación Príncipe Felipe, Eduardo Primo Yúfera, 3, 46012 Valencia, Spain.
Trabanco AA; Neuroscience Medicinal Chemistry, Janssen Research & Development, C/ Jarama 75A, 45007 Toledo, Spain.
Van Glabbeek D; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Vos A; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Tresadern G; Neuroscience Medicinal Chemistry, Discovery Sciences, and Neuroscience Biology, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.

ACS Omega ; 2(2): 685-697, 2017 Feb 28.

Article en En | MEDLINE | ID: mdl-28626832

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: ACS Omega Año: 2017 Tipo del documento: Article País de afiliación: Bélgica

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