Cytochrome P-450-mediated O-demethylation of two ellipticine derivatives. Differential effect of the murine Ah locus phenotype.
Drug Metab Dispos
; 13(4): 497-502, 1985.
Article
en En
| MEDLINE
| ID: mdl-2863116
ABSTRACT
The O-demethylation of two antitumor drugs (9-methoxyellipticine and a 1-polyalkylamino-substituted analog) was studied by incubation with liver microsomes from rats and mice. The former drug underwent a cytochrome P1-450-independent biotransformation in mice, as shown by an indiscriminate response from individuals genetically responsive or nonresponsive to induction by 3-methylcholanthrene. On the other hand, the second drug was O-demethylated only by genetically responsive mice after pretreatment by 3-methylcholanthrene. It was also O-demethylated predominantly in rats pretreated with either 3-methylcholanthrene or Aroclor 1254.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hidrocarburo de Aril Hidroxilasas
/
Sistema Enzimático del Citocromo P-450
/
Elipticinas
/
Alcaloides
Límite:
Animals
Idioma:
En
Revista:
Drug Metab Dispos
Asunto de la revista:
FARMACOLOGIA
Año:
1985
Tipo del documento:
Article