Effect of 6-hydroxydopamine on the metabolism of endogenous octopamines and catecholamines.
J Pharm Pharmacol
; 37(7): 496-7, 1985 Jul.
Article
en En
| MEDLINE
| ID: mdl-2863356
ABSTRACT
The daily excretion in rat urine of o-(OHMA) (0.2), m-(MHMA) (0.9), p-(PHMA) hydroxymandelic acid (78), vanillylmandelic acid (VMA) (3.5) and homovanillic acid (30 micrograms day-1), terminal metabolites of the isomeric octopamines and catecholamines, has been determined by gas chromatography-mass spectrometry. Chemical sympathectomy with 6-hydroxydopamine (i.p.) caused the daily output of each acid (except OHMA) to drop by 50% and that of PHMA was restored to normal the most rapidly after cessation of treatment. These results indicate that m- and p- (but not o-) octopamine coexist with catecholamines in sympathetic nerve terminals, are subject to the same compensatory biosynthetic mechanism following chemical sympathectomy and that p-octopamine has the highest turnover rate of these biogenic amines in the rat.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Catecolaminas
/
Octopamina
/
Hidroxidopaminas
Límite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Año:
1985
Tipo del documento:
Article