The effects of inflammatory cytokines on the expression of ghrelin.
Endocr J
; 64(Suppl.): S25-S26, 2017.
Article
en En
| MEDLINE
| ID: mdl-28652539
ABSTRACT
In the current study, we examined the effects of LPS and inflammatory cytokines including IL-1ß, TNF-α, and IL-6 on the expression of ghrelin in MGN3-1 cells. We found that IL-1ß, and TNF-α with lesser extent, significantly suppressed ghrelin mRNA expression in the cells. MGN3-1 cells expressed IL-1ß receptor and IL-1ß significantly stimulated NF-κB, p38, JNK, and ERK pathways. Knockdown of IKK2 by siRNA significantly attenuated the suppression of ghrelin mRNA by IL-1ß. These results indicate that IL-1ß directly suppressed ghrelin mRNA via NF-κB pathway at least partially, which may have a role in the regulation of appetite during inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Interleucina-1beta
/
Ghrelina
Límite:
Animals
Idioma:
En
Revista:
Endocr J
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP