Controlled release of Doxycycline from gum acacia/poly(sodium acrylate) microparticles for oral drug delivery.
Int J Biol Macromol
; 104(Pt A): 1064-1071, 2017 Nov.
Article
en En
| MEDLINE
| ID: mdl-28668612
ABSTRACT
In the present work, Doxycycline loaded gum acacia (GA)/poly(sodium acrylate) (SA) hydrogels were prepared for the oral drug delivery of model drug Doxycycline. The hydrogels were characterized by X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM) and Zeta potential. The dynamic release of Doxycycline was investigated in the physiological fluids at 37°C. Various kinetic models such as Power function model, Schott model and Higuchi model were applied to interpret the release data. Schott model was found to be most fitted. The Doxycycline loaded hydrogels were tested for their antibacterial action against E. coli.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resinas Acrílicas
/
Portadores de Fármacos
/
Doxiciclina
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Goma Arábiga
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Microesferas
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2017
Tipo del documento:
Article