A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.
Br J Dermatol
; 177(6): 1664-1670, 2017 12.
Article
en En
| MEDLINE
| ID: mdl-28672053
ABSTRACT
BACKGROUND:
Diabetic foot ulcers (DFUs) are a devastating complication of diabetes.OBJECTIVES:
To identify genetic contributors to the development of DFUs in the presence of peripheral neuropathy in a Scottish cohort with diabetes using a genome-wide association study.METHODS:
A genome-wide association approach was applied. A case was defined as a person with diabetes (type 1 or type 2) who had ever had a foot ulcer (current or previous) in at least one foot, as well as a positive monofilament test result (i.e. evidence of peripheral neuropathy) recorded in their longitudinal e-health records. A control was defined as an individual with diabetes (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot but who had a positive monofilament test result recorded in either foot in their longitudinal e-health records.RESULTS:
There were 699 DFU cases and 2695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The single-nucleotide polymorphism rs80028505 (Chr6p21·31) in MAPK14 reached genome-wide significance with a lowest P-value of 2·45 × 10-8 . The narrow-sense heritability of this phenotype is 0·06.CONCLUSIONS:
We suggest that MAPK14 is associated with DFUs.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pie Diabético
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Polimorfismo de Nucleótido Simple
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Proteína Quinasa 14 Activada por Mitógenos
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Diabetes Mellitus Tipo 1
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Diabetes Mellitus Tipo 2
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Br J Dermatol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido