Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI<sub>2</sub> : a safer alternative to COX-2 inhibition.

Ozen, Gulsev; Gomez, Ingrid; Daci, Armond; Deschildre, Catherine; Boubaya, Lilia; Teskin, Onder; Uydes-Dogan, B Sonmez; Jakobsson, Per-Johan; Longrois, Dan; Topal, Gokce; Norel, Xavier

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI₂ : a safer alternative to COX-2 inhibition.

Ozen, Gulsev; Gomez, Ingrid; Daci, Armond; Deschildre, Catherine; Boubaya, Lilia; Teskin, Onder; Uydes-Dogan, B Sonmez; Jakobsson, Per-Johan; Longrois, Dan; Topal, Gokce; Norel, Xavier.

Afiliación

Ozen G; INSERM U1148, Paris, France.
Gomez I; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, Istanbul, Turkey.
Daci A; INSERM U1148, Paris, France.
Deschildre C; Department of Infection, Immunity and Cardiovascular Disease, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK.
Boubaya L; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, Istanbul, Turkey.
Teskin O; INSERM U1148, Paris, France.
Uydes-Dogan BS; INSERM U1148, Paris, France.
Jakobsson PJ; Department of Cardiovascular Surgery, Aile Hospital, Istanbul, Turkey.
Longrois D; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, Istanbul, Turkey.
Topal G; Unit of Rheumatology, Department of Medicine Solna, Karolinska Institute and Unit of Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
Norel X; INSERM U1148, Paris, France.

Br J Pharmacol ; 174(22): 4087-4098, 2017 Nov.

Article en En | MEDLINE | ID: mdl-28675448

Asunto(s)

Epoprostenol/fisiología; Arterias Mamarias/fisiología; Prostaglandina-E Sintasas/fisiología; Vena Safena/fisiología; Anciano; Ciclooxigenasa 2/metabolismo; Ciclooxigenasa 2/fisiología; Inhibidores de la Ciclooxigenasa/farmacología; Epoprostenol/metabolismo; Femenino; Humanos; Inflamación/metabolismo; Inflamación/fisiopatología; Masculino; Arterias Mamarias/efectos de los fármacos; Arterias Mamarias/metabolismo; Persona de Mediana Edad; Norepinefrina/farmacología; Prostaglandina-E Sintasas/antagonistas & inhibidores; Prostaglandina-E Sintasas/metabolismo; Vena Safena/efectos de los fármacos; Vena Safena/metabolismo; Tiofenos/farmacología; Vasoconstrictores/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vena Safena / Epoprostenol / Prostaglandina-E Sintasas / Arterias Mamarias Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

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