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Systems modelling ageing: from single senescent cells to simple multi-cellular models.
Martinez Guimera, Alvaro; Welsh, Ciaran; Dalle Pezze, Piero; Fullard, Nicola; Nelson, Glyn; Roger, Mathilde F; Przyborski, Stefan A; Shanley, Daryl P.
Afiliación
  • Martinez Guimera A; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K.
  • Welsh C; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K.
  • Dalle Pezze P; The Babraham Institute, Babraham Campus, Cambridge, U.K.
  • Fullard N; School of Biological and Biomedical Sciences, Durham University, Durham, U.K.
  • Nelson G; The Bio-Imaging Unit, William Leech Building, William Leech Building, Newcastle Upon Tyne, U.K.
  • Roger MF; School of Biological and Biomedical Sciences, Durham University, Durham, U.K.
  • Przyborski SA; School of Biological and Biomedical Sciences, Durham University, Durham, U.K.
  • Shanley DP; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K. daryl.shanley@ncl.ac.uk.
Essays Biochem ; 61(3): 369-377, 2017 07 15.
Article en En | MEDLINE | ID: mdl-28698310
ABSTRACT
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Biología de Sistemas Límite: Animals / Humans Idioma: En Revista: Essays Biochem Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Biología de Sistemas Límite: Animals / Humans Idioma: En Revista: Essays Biochem Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido