Your browser doesn't support javascript.
loading
l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria.
Ghosh, Chandradhish; Sarkar, Paramita; Samaddar, Sandip; Uppu, Divakara S S M; Haldar, Jayanta.
Afiliación
  • Ghosh C; Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, Karnataka, India. jayanta@jncasr.ac.in.
  • Sarkar P; Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, Karnataka, India. jayanta@jncasr.ac.in.
  • Samaddar S; Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, Karnataka, India. jayanta@jncasr.ac.in.
  • Uppu DSSM; Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, Karnataka, India. jayanta@jncasr.ac.in.
  • Haldar J; Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru 560064, Karnataka, India. jayanta@jncasr.ac.in.
Chem Commun (Camb) ; 53(60): 8427-8430, 2017 Jul 25.
Article en En | MEDLINE | ID: mdl-28702588
ABSTRACT
l-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit cell-wall biosynthesis. The most selective compound bore promising activity against biofilm-related infections and intracellular bacteria, and also suppressed the stimulation of TNF-α induced by lipoteichoic acid. Belligerent to resistance development, it was active in a murine model of MRSA infection.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bifenilo / Antiinflamatorios no Esteroideos / Biopelículas / Staphylococcus aureus Resistente a Meticilina / Lípidos / Lisina / Antibacterianos Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Bifenilo / Antiinflamatorios no Esteroideos / Biopelículas / Staphylococcus aureus Resistente a Meticilina / Lípidos / Lisina / Antibacterianos Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: India