Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.

Shen, Fa-Qian; Wang, Zhong-Chang; Wu, Song-Yu; Ren, Shen-Zhen; Man, Ruo-Jun; Wang, Bao-Zhong; Zhu, Hai-Liang

Shen, Fa-Qian; Wang, Zhong-Chang; Wu, Song-Yu; Ren, Shen-Zhen; Man, Ruo-Jun; Wang, Bao-Zhong; Zhu, Hai-Liang.

Afiliación

Shen FQ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China.
Wang ZC; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China.
Wu SY; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China.
Ren SZ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China.
Man RJ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China.
Wang BZ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China.
Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China. Electronic address: zhuhl@nju.edu.cn.

Bioorg Med Chem Lett ; 27(16): 3653-3660, 2017 08 15.

Article en En | MEDLINE | ID: mdl-28720504

Asunto(s)

Cumarinas/química; Cumarinas/farmacología; Ciclooxigenasa 2/metabolismo; Pirazoles/química; Pirazoles/farmacología; Células A549; Apoptosis/efectos de los fármacos; Araquidonato 5-Lipooxigenasa/química; Araquidonato 5-Lipooxigenasa/metabolismo; Sitios de Unión; Dominio Catalítico; Puntos de Control del Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Ciclooxigenasa 2/química; Inhibidores de la Ciclooxigenasa 2/síntesis química; Inhibidores de la Ciclooxigenasa 2/química; Inhibidores de la Ciclooxigenasa 2/farmacología; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Concentración 50 Inhibidora; Inhibidores de la Lipooxigenasa/síntesis química; Inhibidores de la Lipooxigenasa/química; Inhibidores de la Lipooxigenasa/farmacología; Simulación del Acoplamiento Molecular; Relación Estructura-Actividad

Palabras clave

5-LOX; COX-2; Cancer; Coumarin; Pyrazole

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Cumarinas / Ciclooxigenasa 2 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google