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A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity.
Massignan, Tania; Sangiovanni, Valeria; Biggi, Silvia; Stincardini, Claudia; Elezgarai, Saioa R; Maietta, Giulia; Andreev, Ivan A; Ratmanova, Nina K; Belov, Dmitry S; Lukyanenko, Evgeny R; Belov, Grigory M; Barreca, Maria Letizia; Altieri, Andrea; Kurkin, Alexander V; Biasini, Emiliano.
Afiliación
  • Massignan T; Dulbecco Telethon Laboratory of Prions and Amyloids, Centre for Integrative Biology, CIBIO, University of Trento, 38123, Trento, Italy.
  • Sangiovanni V; Dulbecco Telethon Laboratory of Prions and Amyloids, Centre for Integrative Biology, CIBIO, University of Trento, 38123, Trento, Italy.
  • Biggi S; Dulbecco Telethon Laboratory of Prions and Amyloids, Centre for Integrative Biology, CIBIO, University of Trento, 38123, Trento, Italy.
  • Stincardini C; Dulbecco Telethon Laboratory of Prions and Amyloids, Centre for Integrative Biology, CIBIO, University of Trento, 38123, Trento, Italy.
  • Elezgarai SR; Dulbecco Telethon Laboratory of Prions and Amyloids, Centre for Integrative Biology, CIBIO, University of Trento, 38123, Trento, Italy.
  • Maietta G; Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156, Milan, Italy.
  • Andreev IA; Department of Neuroscience, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156, Milan, Italy.
  • Ratmanova NK; Dulbecco Telethon Laboratory of Prions and Amyloids, Centre for Integrative Biology, CIBIO, University of Trento, 38123, Trento, Italy.
  • Belov DS; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
  • Lukyanenko ER; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
  • Belov GM; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
  • Barreca ML; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
  • Altieri A; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
  • Kurkin AV; EDASA Scientific srls, 66050, San Salvo, CH, Italy.
  • Biasini E; Department of Pharmaceutical Sciences, University of Perugia, 06123, Perugia, Italy.
ChemMedChem ; 12(16): 1286-1292, 2017 08 22.
Article en En | MEDLINE | ID: mdl-28722340
ABSTRACT
Into the fold Prion diseases are neurodegenerative disorders characterized by the accumulation in the brain of a self-replicating, misfolded isoform (PrPSc ) of the cellular prion protein (PrPC ). No therapies are available for these pathologies. We capitalized on previously described cell-based assays to screen a library of small molecules, and identified 55, a compound capable of counteracting both prion replication and toxicity. Compound 55 may represent the starting point for the development of a completely new class of therapeutics for prion diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bibliotecas de Moléculas Pequeñas / Proteínas Priónicas Límite: Animals / Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bibliotecas de Moléculas Pequeñas / Proteínas Priónicas Límite: Animals / Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Italia