Alzheimer's disease markers in the aged sheep (Ovis aries).
Neurobiol Aging
; 58: 112-119, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28728117
ABSTRACT
This study reports the identification and characterization of markers of Alzheimer's disease (AD) in aged sheep (Ovis aries) as a preliminary step toward making a genetically modified large animal model of AD. Importantly, the sequences of key proteins involved in AD pathogenesis are highly conserved between sheep and human. The processing of the amyloid-ß (Aß) protein is conserved between sheep and human, and sheep Aß1-42/Aß1-40 ratios in cerebrospinal fluid (CSF) are also very similar to human. In addition, total tau and neurofilament light levels in CSF are comparable with those found in human. The presence of neurofibrillary tangles in aged sheep brain has previously been established; here, we report for the first time that plaques, the other pathologic hallmark of AD, are also present in the aged sheep brain. In summary, the biological machinery to generate the key neuropathologic features of AD is conserved between the human and sheep, making the sheep a good candidate for future genetic manipulation to accelerate the condition for use in pathophysiological discovery and therapeutic testing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Animales Modificados Genéticamente
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Péptidos beta-Amiloides
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Proteínas de Neurofilamentos
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Proteínas tau
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Modelos Animales de Enfermedad
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Enfermedad de Alzheimer
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neurobiol Aging
Año:
2017
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda