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Thymosin beta-4 overexpression correlates with high-risk groups in gastric gastrointestinal stromal tumors: A retrospective analysis by immunohistochemistry.
Sahin, Sevinç; Ekinci, Ozgur; Seçkin, Selda; Dursun, Ayse.
Afiliación
  • Sahin S; Bozok University School of Medicine, Department of Pathology, Adnan Menderes Bulvari, No: 44, 66200, Yozgat, Turkey. Electronic address: sevcelik82@gmail.com.
  • Ekinci O; Gazi University School of Medicine, Department of Pathology, 06500, Besevler, Ankara, Turkey.
  • Seçkin S; Bozok University School of Medicine, Department of Pathology, Adnan Menderes Bulvari, No: 44, 66200, Yozgat, Turkey.
  • Dursun A; Gazi University School of Medicine, Department of Pathology, 06500, Besevler, Ankara, Turkey.
Pathol Res Pract ; 213(9): 1139-1143, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28756979
BACKGROUND: Thymosin beta-4 (Tß4) is a protein that is linked to a number of important biological actions and recently tumor progression and poor prognosis of some tumors. The aim of this study was to evaluate Tß4 expression in gastric GISTs and correlate with some clinicopathological characteristics related with prognosis and clinical outcome in order to add further data to the current literature. METHODS: Tß4 antibody was applied to the 4µm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry. RESULTS: Tß4 expression was found to be directly corrrelated with higher risk groups, tumor size, mitotic count, cellularity, and necrosis while it was inversely correlated with overall survival (OS) by univariate analysis (p=0.000, p=0.001, p=0.000, p=0.025, p=0.023, and p=0.042, respectively). The direct association between Tß4 expression and risk groups were also supported by multivariate analysis (p=0.000, ß=0.497, t=4.374). CONCLUSION: Overexpression of Tß4 was found to be related with predictive characteristics for tumor progression and adverse prognosis. Thus, we suggest that overexpression of Tß4 might play a role in the progression of gastric GISTs and might be used as a potential prognostic tool as well as a target for novel therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timosina / Biomarcadores de Tumor / Tumores del Estroma Gastrointestinal / Neoplasias Gastrointestinales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Año: 2017 Tipo del documento: Article Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timosina / Biomarcadores de Tumor / Tumores del Estroma Gastrointestinal / Neoplasias Gastrointestinales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Año: 2017 Tipo del documento: Article Pais de publicación: Alemania