Is TFIIH the new Achilles heel of cancer cells?
Transcription
; 9(1): 47-51, 2018.
Article
en En
| MEDLINE
| ID: mdl-28792271
ABSTRACT
TFIIH is a 10-subunit complex involved in transcription and DNA repair. It contains several enzymatic activities including a ATP-dependent DNA translocase in XPB and a cyclin-dependent kinase in CDK7. Recently the discovery of several XPB and CDK7 inhibitors with specific impact on the transcriptional addiction of many tumors pinpointed these activities as potential target in cancer chemotherapy. Unexpectedly a basal transcription factor involved in global mRNA expression now emerges a one of the most clinically promising Achilles heels of cancerous cells. These inhibitors also proved to be useful tools to unveil new functions of TFIIH in gene expression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
Reparación del ADN
/
Factor de Transcripción TFIIH
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Transcription
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia