Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.

Wang, Jin; Cai, Pei; Yang, Xue-Lian; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing

Wang, Jin; Cai, Pei; Yang, Xue-Lian; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing.

Afiliación

Wang J; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Cai P; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Yang XL; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Li F; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Wu JJ; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address: cpu_lykong@126.com.
Wang XB; Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address: xbwang@cpu.edu.cn.

Eur J Med Chem ; 139: 68-83, 2017 Oct 20.

Article en En | MEDLINE | ID: mdl-28800459

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Antioxidantes/farmacología; Bencilaminas/farmacología; Colinérgicos/farmacología; Inhibidores de la Colinesterasa/farmacología; Cinamatos/farmacología; Fármacos Neuroprotectores/farmacología; Acetilcolinesterasa/metabolismo; Animales; Antioxidantes/síntesis química; Antioxidantes/química; Bencilaminas/química; Barrera Hematorretinal/efectos de los fármacos; Butirilcolinesterasa/metabolismo; Muerte Celular/efectos de los fármacos; Colinérgicos/síntesis química; Colinérgicos/química; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/química; Cinamatos/química; Relación Dosis-Respuesta a Droga; Humanos; Estructura Molecular; Fármacos Neuroprotectores/síntesis química; Fármacos Neuroprotectores/química; Estrés Oxidativo/efectos de los fármacos; Células PC12; Ratas; Relación Estructura-Actividad

Palabras clave

AP2238; Alzheimer's disease; Antioxidant activity; Cholinesterase; Cinnamamide

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bencilaminas / Inhibidores de la Colinesterasa / Cinamatos / Fármacos Neuroprotectores / Colinérgicos / Enfermedad de Alzheimer / Antioxidantes Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article Pais de publicación: Francia

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