Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.
Bioorg Med Chem Lett
; 27(18): 4462-4466, 2017 09 15.
Article
en En
| MEDLINE
| ID: mdl-28807439
ABSTRACT
A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity. This chemotype represents a stepping stone towards chemical probes to study the consequences of lipid metabolism modulation through non-redundant pathways.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Estearoil-CoA Desaturasa
/
Tiofenos
/
Inhibidores Enzimáticos
/
Ácidos Grasos
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2017
Tipo del documento:
Article