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Molecular Memory of Morphologies by Septins during Neuron Generation Allows Early Polarity Inheritance.
Boubakar, Leila; Falk, Julien; Ducuing, Hugo; Thoinet, Karine; Reynaud, Florie; Derrington, Edmund; Castellani, Valérie.
Afiliación
  • Boubakar L; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France.
  • Falk J; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France. Electronic address: julien.falk@univ-lyon1.fr.
  • Ducuing H; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France.
  • Thoinet K; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France.
  • Reynaud F; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France.
  • Derrington E; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France.
  • Castellani V; NeuroMyoGene Institute UMR CNRS 5310 INSERM U 1217, University of Lyon, University of Lyon 1 Claude Bernard Lyon 1, 16 rue Raphael Dubois, 69000 Lyon, France. Electronic address: valerie.castellani@univ-lyon1.fr.
Neuron ; 95(4): 834-851.e5, 2017 Aug 16.
Article en En | MEDLINE | ID: mdl-28817802
Transmission of polarity established early during cell lineage history is emerging as a key process guiding cell differentiation. Highly polarized neurons provide a fascinating model to study inheritance of polarity over cell generations and across morphological transitions. Neural crest cells (NCCs) migrate to the dorsal root ganglia to generate neurons directly or after cell divisions in situ. Using live imaging of vertebrate embryo slices, we found that bipolar NCC progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor. Monitoring the dynamics of Septins, which play key roles in yeast polarity, indicates that Septin 7 tags process sites for re-initiation of process growth following mitosis. Interfering with Septins blocks this mechanism. Thus, Septins store polarity features during mitotic rounding so that daughters can reconstitute the initial progenitor polarity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polaridad Celular / Regulación del Desarrollo de la Expresión Génica / Forma de la Célula / Neurogénesis / Septinas / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polaridad Celular / Regulación del Desarrollo de la Expresión Génica / Forma de la Célula / Neurogénesis / Septinas / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos