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Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.
Govindpani, Karan; Calvo-Flores Guzmán, Beatriz; Vinnakota, Chitra; Waldvogel, Henry J; Faull, Richard L; Kwakowsky, Andrea.
Afiliación
  • Govindpani K; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand. k.govindpani@auckland.ac.nz.
  • Calvo-Flores Guzmán B; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand. b.guzman@auckland.ac.nz.
  • Vinnakota C; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand. c.vinnakota@auckland.ac.nz.
  • Waldvogel HJ; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand. h.waldvogel@auckland.ac.nz.
  • Faull RL; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand. rlm.faull@auckland.ac.nz.
  • Kwakowsky A; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand. a.kwakowsky@auckalnd.ac.nz.
Int J Mol Sci ; 18(8)2017 Aug 21.
Article en En | MEDLINE | ID: mdl-28825683
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain. In the past, there has been a major research drive focused on the dysfunction of the glutamatergic and cholinergic neurotransmitter systems in Alzheimer's disease (AD). However, there is now growing evidence in support of a GABAergic contribution to the pathogenesis of this neurodegenerative disease. Previous studies paint a complex, convoluted and often inconsistent picture of AD-associated GABAergic remodeling. Given the importance of the GABAergic system in neuronal function and homeostasis, in the maintenance of the excitatory/inhibitory balance, and in the processes of learning and memory, such changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis. Given the limited scope of currently available therapies in modifying the course of the disease, a better understanding of GABAergic remodeling in AD could open up innovative and novel therapeutic opportunities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurotransmisores / Neuronas GABAérgicas / Enfermedad de Alzheimer / Ácido gamma-Aminobutírico Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurotransmisores / Neuronas GABAérgicas / Enfermedad de Alzheimer / Ácido gamma-Aminobutírico Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Suiza