Synthesis of a novel structure for the oral delivery of insulin and the study of its effect on diabetic rats.
Life Sci
; 186: 43-49, 2017 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-28827153
ABSTRACT
Common materials used for drug delivery in the body are liposomes, micelles, polymer capsules, dendrimers, nanoparticles, porous materials, etc. Drug delivery system should be inert, biodegradable, have high biocompatibility and the ability to load large amounts of the drug with known concentration while having a simple and economical sterilizing process. In this study we produced mesoporous silica nanostructures coated with polyamide amine dendrimer that were placed in chitosan-gelatin scaffolds. At every step of the synthesis, the products were identified using different methods, including XRD, FT-IR, SEM, and TGA. The final drug was studied in terms of in vitro & in vivo and MTT toxicity was evaluated.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Dióxido de Silicio
/
Dendrímeros
/
Nanopartículas
/
Hipoglucemiantes
/
Insulina
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
2017
Tipo del documento:
Article